Clinical Trial: The Outcomes of Arteriovenous Fistula Cannulated From Different Direction.

Study Status: Terminated
Recruit Status: Terminated
Study Type: Interventional

Official Title: The Outcomes of Arteriovenous Fistula (AVF) Cannulated From Different Direction in Maintenance Hemodialysis Patients.

Brief Summary: The investigators hypothesis that aneurysms and stenoses will be decreased if the direction of inserted arterial needle were same as the direction of blood flow, when compared to the opposite direction puncture.

Detailed Summary: Native arteriovenous fistula (AVF) is the preferred access for hemodialysis, and cannulation technique is very important factors affect the outcomes of AVF. Rope-ladder cannulation is one kind of the standard puncture techniques which is used commonly in maintenance hemodialysis (MHD) patients. There are many complications for rope-ladder cannulation, such as venous aneurysm and vascular stenosis, which may induce AVF dysfunction. For the venous outflow way, there always be aneurysm followed by stenoses at the sites of needle connected with the arterial line in rope-ladder cannulation patients. The investigators hypothesis that the directions of inserted arterial needles should affect the AVF outcomes. The present prospective study will compare the outcomes of AVF between the puncture direction at arterial needle sites same as blood flow and opposite to blood flow.
Sponsor: Dongliang Zhang, MD

Current Primary Outcome: Prevalence of AVF aneurysm and stenosis. [ Time Frame: 12 months ]

Compare the prevalence of AVF aneurysm and stenosis between two groups during 12 months.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Proportions of AVF dysfunction in different groups. [ Time Frame: 12 months ]
    Compare the proportions of AVF dysfunction between two groups during 12 months.
  • The size of venous aneurysm. [ Time Frame: 12 months ]
    Measure the maximum size of venous aneurysm by using ultrasonography at month 12.
  • Diameter of venous stenosis. [ Time Frame: 12 months ]
    Measure the minimum diameter of venous stenosis by ultrasonography at month 12.
  • Percentages of unsuccessful cannulations. [ Time Frame: 12 months ]
    Unsuccessful cannulations include mis-cannulation, cannulation ease, hematoma, more than once cannulation at arterial site.
  • Events of AVF obstruction. [ Time Frame: 12 months ]
    AVF obstruction and the following treatments as central venous catheters and interventions will be recorded and compared between two groups during 12 months.


Original Secondary Outcome:

  • Proportions of AVF dysfunction in different groups. [ Time Frame: 12 months ]
    Compare the proportions of AVF dysfunction between two groups during 12 months.
  • The size of venous aneurysm. [ Time Frame: 12 months ]
    Mearure the maxium size of venous aneurysm by using ultrasonagrphy at month 12.
  • Diameter of venous stenosis. [ Time Frame: 12 months ]
    Measure the minimum diameter of venous stenosis by ultrasonagraphy at month 12.
  • Percentages of unsuccessful cannulations. [ Time Frame: 12 months ]
    Unsuccessful cannulations include miscannulation, cannulation ease, heamatoma, more than once cannulation at arterial site.
  • Events of AVF obstruction. [ Time Frame: 12 months ]
    AVF obstrucion and the following treatments as cetral venous catheters and interventions will be recorded and compared between two groups during 12 months.


Information By: Capital Medical University

Dates:
Date Received: July 12, 2012
Date Started: September 2012
Date Completion:
Last Updated: May 19, 2015
Last Verified: May 2015