Clinical Trial: Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Investigating the Use of Transcranial Magnetic Stimulation (TMS) for Primary Progressive Apraxia of Speech (PPAOS)
Brief Summary: The purpose of this study is to assess the influence of transcranial magnetic stimulation (TMS) on speech performance in individuals with primary progressive apraxia of speech.
Detailed Summary:
Apraxia of speech (AOS) is a motor speech disorder affecting the programming of motor speech production. It is characterized by the impaired ability to coordinate the sequential, articulatory movements necessary to produce speech sound. It can result from insult to the brain, such as in stroke, or as the presenting sign/symptom of another neurodegenerative disease.
TMS is a neurostimulation technique which has been shown to modulate cortical excitability in a non-invasive manner, and has been associated with positive outcomes in a variety of neurological and psychological disorders.There is evidence to support the role of TMS in individuals with primary progressive aphasias. In addition, there is a a case report suggesting an improvement in speech following TMS in an individual with primary progressive AOS. This study is being undertaken to further examine the role of TMS in primary progressive AOS.
Sponsor: University of Miami
Current Primary Outcome: Change in Speech Performance [ Time Frame: Baseline and following 10 sessions of rTMS over a 2 week period ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Change in motor cortex excitability [ Time Frame: Baseline and following 10 sessions of rTMS over a 2 week period ]
Original Secondary Outcome: Same as current
Information By: University of Miami
Dates:
Date Received: January 16, 2017
Date Started: January 2017
Date Completion: December 2018
Last Updated: January 20, 2017
Last Verified: January 2017