Clinical Trial: Gastrointestinal Microbiome Study of Appendiceal Cancer

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Cohort Study of the Gastrointestinal Microbiome in Appendiceal Cancer With Peritoneal Spread

Brief Summary: This study analyzes the gastrointestinal microbiome of appendiceal cancer patients with peritoneal spread scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Participants will provide fecal samples pre- and post-operatively.

Detailed Summary:

Analysis of the human microbiome is an attempt to define how changes in the human microbiome are associated with health or disease.

Eligible participants scheduled to undergo cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for appendiceal cancer will provide fecal samples pre- and post-operatively. Investigators will analyze potential changes in the gastrointestinal microbiome and make comparisons to an age-matched healthy sample.

Sponsor: Mercy Medical Center

Current Primary Outcome: Determine whether the intestinal microbiome of patients with appendiceal tumors with peritoneal carcinomatosis differs from that of a healthy, age-matched cohort [ Time Frame: 36 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Compare the gut microbiome of appendiceal tumors by histopathology [ Time Frame: 36 months ]

Original Secondary Outcome: Same as current

Information By: Mercy Medical Center

Dates:
Date Received: November 4, 2015
Date Started: December 2015
Date Completion: December 2018
Last Updated: September 12, 2016
Last Verified: September 2016