Clinical Trial: Fat Distribution and Glucose Metabolism in Williams Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Characterization of Fat Distribution and Glucose Metabolism in Individuals With and Without Williams Syndrome

Brief Summary: Williams Syndrome (WS) is a genetic syndrome with features that may include vascular stenoses, neuro-developmental changes, and a variety of endocrine and metabolic abnormalities, including impaired glucose metabolism and abnormal body composition. Approximately 75% of adults with WS have impaired glucose tolerance or diabetes on oral glucose tolerance testing (OGTT). In addition, clinical observations and preliminary data suggest increased overall body fat in these individuals, as well as a relative increase in fat deposition in the lower extremities. However, glucose and lipid metabolism in WS remain incompletely characterized. The purpose of the current study is to carefully describe glucose metabolism and lipid parameters in people with WS.

Detailed Summary:
Sponsor: Massachusetts General Hospital

Current Primary Outcome: 2-hour glucose [ Time Frame: Baseline ]

Blood glucose concentration two hours after drinking a sugary drink (oral glucose tolerance test)


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Percent body fat [ Time Frame: Baseline ]
    percent body fat as measured by whole body dual-energy xray absorptiometry (DXA) scanning
  • Low-density lipoprotein cholesterol (LDL) [ Time Frame: Baseline ]


Original Secondary Outcome: Same as current

Information By: Massachusetts General Hospital

Dates:
Date Received: May 10, 2013
Date Started: December 2013
Date Completion:
Last Updated: January 6, 2017
Last Verified: January 2017