Clinical Trial: Pro-inflammatory Cytokines in Blood From Orthopedic Surgery Compared to Abdominal Aneurysm Repair

Study Status: Terminated
Recruit Status: Unknown status
Study Type: Observational

Official Title: Pro-inflammatory Cytokines (IL-1beta,IL-6, IL-8 and TNF-α) and Complement Activation (C3a) in Blood Collected From Surgery Field From Patients Undergoing Orthopedic Surgery Compared to Patients U

Brief Summary: The purpose of this study is to investigate the contents in blood sampled from surgery site during hip replacement compared with blood sampled from abdominal aortic surgery. Is there any difference in pro-inflammatory cytokines (IL-1beta, IL-6, IL-8 and TNF-α), complement activation (C3a)?

Detailed Summary:

Patient (n= 10) scheduled for total hip replacement or hemiprosthesis and patient (n=10) scheduled for abdominal aortic surgery.

Primary outcome:

Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups.

Secondary outcome:

Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups.

Sponsor: Sykehuset i Vestfold HF

Current Primary Outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in blood samples collected from surgery field. Comparison between the 2 groups. [ Time Frame: 30 days ]

Original Primary Outcome: Pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) and complement activation (C3a) in bloodsamples collected from surgeryfield. Comparison between the 2 groups. [ Time Frame: 30 days ]

Current Secondary Outcome: Haemoglobin, Trc, INR in blood samples and plasma will be analysed and compared between the 2 groups. [ Time Frame: 30 days ]

Original Secondary Outcome: Haemoglobin, Trc, INR in bloodsamples and plasma will be analysed and compared between the 2 groups. [ Time Frame: 30 days ]

Information By: Sykehuset i Vestfold HF

Dates:
Date Received: February 23, 2009
Date Started: November 2009
Date Completion: May 2010
Last Updated: June 10, 2010
Last Verified: June 2010