Clinical Trial: Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast Magnetic Resonance Imaging (MRI)

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Evaluation of Vascular Pathology With 3D, Time-Resolved Phase Contrast MRI

Brief Summary:

Aortic coarctation is a relatively common cardiovascular condition with high associated mortality if not treated. Even with successful repair, however, close follow up is needed as late complications can result in significant cardiovascular morbidity. MRI, with is ability to provide both anatomic and hemodynamic information, is becoming the imaging option of choice for post-intervention surveillance. Time-resolved, three-dimensional phase contrast magnetic resonance velocity (4D Flow) profiling enables the acquisition of multidirectional blood velocity data. The technique is well suited for evaluation of blood flow patterns in the thoracic aorta. By comparing aortic flow patterns in patients status post coarctation repair with those of healthy volunteers using 4D Flow, this study intends to characterize abnormal flow patterns in these patients with the eventual goal of better understanding and predicting late complications so that preemptive intervention may be taken.

Given the potential use of 4D Flow for evaluation of other types of vascular pathology in the aorta and other vascular regions, we hope to investigate the use of the technique on a limited basis for a broader population of adult patients. Other research groups have had success evaluating peripheral stenoses, as well as intracardiac and intracranial blood flow patterns with 4D Flow.

Detailed Summary:
Sponsor: University of California, San Francisco

Current Primary Outcome: predicting late complications in patients status post coarctation repair so that preemptive intervention may be taken [ Time Frame: For at least three years following the completion of the study, the database of patients will be updated for clinically relevant information ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of California, San Francisco

Dates:
Date Received: July 24, 2008
Date Started: June 2007
Date Completion:
Last Updated: October 4, 2013
Last Verified: October 2013