Clinical Trial: Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype
Brief Summary: The main objective of this study is to investigate the correlation between the rate of motor decline and blood levels of Vitamin D total. Secondary objectives are to investigate the relationship between blood levels of vitamin D and total disease duration of ALS, forced vital capacity, weight loss, age of onset and the start site of ALS.
Detailed Summary: Amyotrophic lateral sclerosis is one of the most serious neurodegenerative disease, leading to death in 3 years by progressive paralysis of 4 limbs, speech, swallowing and breathing, and due to a progressive death of central and peripheral neurons. The cause of the disease is unknown, but an immunologically factor is more precisely suspected in ALS. Since 2008, the work of Immunology have shown that vitamin D was a major regulator of immunity. It regulates particularly the function of dendritic cells and regulates the immune response in macrophages. A vitamin D deficiency will induce activation of microglia. In neurology, vitamin D deficiency is associated with a greater impairment in neuronal function. This deficit is associated with a faster alteration of the microvasculature, alteration known to increase neuronal suffering and to enhance the neurodegenerative processes. The investigators postulate that ALS patients have a more severe prognosis if their vitamin D levels at the time of diagnosis is lower. The main objective of this study is to investigate the correlation between the rate of motor decline and blood levels of Vitamin D total. Secondary objectives are to investigate the relationship between blood levels of vitamin D and total disease duration of ALS, forced vital capacity, weight loss, age of onset and the start site of ALS.
Sponsor: University Hospital, Montpellier
Current Primary Outcome: Vitamin D blood level [ Time Frame: Day 1 ]
Original Primary Outcome: Vitamin D blood level [ Time Frame: the day of inclusion ]
Current Secondary Outcome:
Original Secondary Outcome:
Information By: University Hospital, Montpellier
Dates:
Date Received: March 22, 2013
Date Started: September 2012
Date Completion:
Last Updated: December 4, 2015
Last Verified: September 2015
