Clinical Trial: The Influence of Cortical Bone Perforation on Guided Bone Regeneration in Humans

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Influence of Cortical Bone Perforation on Guided Bone Regeneration in Humans: A Randomized Clinical Trial

Brief Summary: The purpose of this randomized clinical trial was to evaluate the effect of cortical bone decortication on the angiogenesis and osteogenesis of augmented ridge by GBR.

Detailed Summary:

Background: The purpose of the current study was to evaluate the effect of cortical bone perforation on angiogenesis and osteogenesis of augmented ridge by guided bone regeneration.

Methods: Fourteen patients (mean age: 52) who were in need of dental implants at areas with osseous defects in the mandible were selected. In the test group (n=7), alveolar cortical bone at the area of regeneration was perforated using a #2 high speed round bur. No decortication of cortical bone was performed in the control group (n=7). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, implant sites were created and trephine cores harvested for histological and histomorphometric analysis of the grafted areas.

Sponsor: Mashhad University of Medical Sciences

Current Primary Outcome: The amount of vital bone formation by histomorphometric analysis after cortical bone perforation [ Time Frame: 7 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Mashhad University of Medical Sciences

Dates:
Date Received: April 11, 2016
Date Started: January 2015
Date Completion:
Last Updated: April 15, 2016
Last Verified: April 2016