Clinical Trial: Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison of Post Tooth Extraction Healing Using Different Xenograft Materials

Brief Summary:

The purpose of this pilot study is to conduct a interventional prospective clinical trial to evaluate the efficacy of three different xenografts for ridge preservation by comparing the quality of newly formed bone using histomorphometric and micro CT analysis.The three xenograft materials under investigation are Bio-Oss® (bovine derived xenograft), Equimatrix® (equine derived xenograft), and Endobon® (bovine derived xenograft). There are no prospective studies comparing the effectiveness of these three materials, Bio-Oss®, Endobon® and Equimatrix®, when placed in extraction sockets.

Participants will be recruited from patients in the TUSDM clinics that require extraction of single rooted non-molar tooth and are treatment planned to receive dental implants in the future. Participants will be randomized to receive one of the three xenograft materials after tooth extraction. The percentage of newly formed bone and bone density will be compared between the three materials 4-6 months after ridge preservation.


Detailed Summary:

This is a pilot prospective clinical trial in which histological and micro CT analysis will be utilized to compare between Endobon®, Equimatrix®, and Bio-Oss®.

Primary aim: Compare the percentage of newly formed bone between Equimatrix®, Bio-Oss® and Endobon®.

The investigators hypothesize that the mean percentage of newly formed bone from Equimatrix® will be higher than Bio-Oss® and/or Endobon®.

Secondary aim: Compare the bone density between Equimatrix®, Bio-Oss® and Endobon®.

The investigators hypothesize that the bone density from Equimatrix® will be higher than Bio-Oss® and/or Endobon®.


Sponsor: Tufts University School of Dental Medicine

Current Primary Outcome: Percent New Bone Formation [ Time Frame: 4-6 months after ridge preservation surgery ]

Histomorphometric determination of % new bone formation


Original Primary Outcome: Same as current

Current Secondary Outcome: Bone density [ Time Frame: 4-6 months after ridge preservation surgery ]

Measured by Micro CT Scanning


Original Secondary Outcome: Same as current

Information By: Tufts University School of Dental Medicine

Dates:
Date Received: May 9, 2017
Date Started: October 20, 2014
Date Completion:
Last Updated: May 10, 2017
Last Verified: May 2017