Clinical Trial: Effect of High Altitude Exposure, Acclimatization and Re-exposure on Lung Water Content by Ultrasound
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Effect of High Altitude Exposure, Acclimatization and Re-exposure on Lung Water Content by Ultrasound
Brief Summary: Prospective interventional trial in lowlanders evaluating effect of acute exposure, acclimatization and re-exposure to high altitude.
Detailed Summary:
Low altitude baseline measurements will be performed in Santiago de Chile, 520 m, over the course of 3 days. Participants will then travel by commercial airline (5 h flight) and by bus (3 h ride) to the Atacama large Millimeter Array (ALMA) base camp located at 2900 m near San Pedro de Atacama, northern Chile. Participants will stay there for the next 7 nights and they will be spend the days (6-8 h daily) at the telescope station at 5050 m while undergoing physiological testing. Daily transports from 2900 to 5050 m will be by car (1 h ride, one way). After the first 7 day altitude sojourn participants will return to the Santiago area (520 m) for a 7 day recovery period.
A second altitude sojourn cycle with an identical schedule as the one described above and a final low altitude stay of 3 days will follow.
Measurements on study subjects will be performed at baseline (lowland, Santiago de Chile), then at 2nd day of altitude exposure and 7th day at altitude before returning to lowland; those are repeated in the second altitude sojourn cycle. Measurements will be conducted by qualified specialists using a portable ultrasound device.
Sponsor: University of Zurich
Current Primary Outcome: ultrasound lung comets [ Time Frame: change from lowland baseline at 520m, day 2 and first sojourn at 5050 m, day 2 ]
Original Primary Outcome: Same as current
Current Secondary Outcome: ultrasound lung comets [ Time Frame: first sojourn at 5050 m, 7; second sojourn at 5050m, day 2, 7 ]
Original Secondary Outcome: Same as current
Information By: University of Zurich
Dates:
Date Received: April 12, 2016
Date Started: March 2016
Date Completion:
Last Updated: May 4, 2017
Last Verified: May 2017
