Clinical Trial: Effectiveness of Acetazolamide for Reversal of Metabolic Alkalosis in Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: A Randomized Trial to Evaluate Effectiveness of Acetazolamide in COPD Patients Developing Metabolic Alkalosis During Invasive Mechanical Ventilation

Brief Summary: The purpose of this study is to determine whether acetazolamide are effective to reduce the length of mechanical ventilation in decompensated Chronic Obstructive Pulmonary Disease (COPD) patients developing pure or mixed metabolic alkalosis.

Detailed Summary: The purpose of this study is to determine whether acetazolamide is effective to reduce the length of mechanical ventilation in decompensated COPD patients developing pure or mixed metabolic alkalosis.
Sponsor: Assistance Publique - Hôpitaux de Paris

Current Primary Outcome: length of invasive mechanical ventilation [ Time Frame: within the first 28 days after intubation ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Length of weaning from mechanical ventilation [ Time Frame: once at the extubation or at day 28 ]
    data retrieved once, at the extubation or at the end of invasive ventilation in the tracheotomy
  • weaning success [ Time Frame: once at the end of ICU stay or at Day 28 ]
    Data collected once at the end of ICU stay or at Day 28
  • numbers of nosocomial infections [ Time Frame: every day during 28 days ]
    data retrieved every day, until extubation or at the end of invasive ventilation in the tracheotomy
  • length of ICU stay [ Time Frame: once at the end of ICU stay or at Day 28 ]
    Data collected once at the end of ICU stay or at Day 28
  • ICU mortality [ Time Frame: once at the end of ICU stay or at Day 28 ]
    Data collected once at the end of ICU stay or at Day 28


Original Secondary Outcome: Same as current

Information By: Assistance Publique - Hôpitaux de Paris

Dates:
Date Received: April 2, 2012
Date Started: October 2011
Date Completion:
Last Updated: October 5, 2015
Last Verified: October 2015