Clinical Trial: Acetazolamide Facilitates Ventilator Weaning

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Acetazolamide Facilitates Ventilator Weaning Multicenter, Prospective, Double Blinded, Randomised Controlled Trial

Brief Summary: Metabolic alkalosis(MA) is common metabolic disorder in ICU setting. MA could be cause of weaning failure or delay by depression of respiratory center. The purpose of this study is to evaluate that correction of MA by administration of acetazolamide facilitates weaning of mechanical ventilation.

Detailed Summary:
Sponsor: Asan Medical Center

Current Primary Outcome: weaning time between two group [ Time Frame: hour ]

Weaning time : [total ventilation time] - [total controlled mode time]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Successful weaning rate between two group
    Successful weaning : self respiration more than 48h after withdrawl mechanical ventilation
  • total duration of mechanical ventilation between two group [ Time Frame: hour ]
  • length of ICU stay between two group [ Time Frame: hour ]
  • frequency of ventilator associated pneumonia between two group
  • overall ICU mortality between two group


Original Secondary Outcome: Same as current

Information By: Asan Medical Center

Dates:
Date Received: May 26, 2010
Date Started: May 2010
Date Completion: May 2011
Last Updated: May 26, 2010
Last Verified: April 2010