Clinical Trial: Naltrexone and Memantine Effects on Alcohol Drinking Behaviors

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Glutamate-opioid Interactions in Alcohol Drinking Behaviors

Brief Summary: The purpose of this study is to evaluate the combined effects of the study medications naltrexone and memantine on alcohol drinking behaviors. Participants will be randomized to receive a combination of these medications over a one week period and then participate in a laboratory session. During this session, participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. These medications are hypothesized to reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period.

Detailed Summary:
Sponsor: Yale University

Current Primary Outcome: number of drinks consumed [ Time Frame: 1 month ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Stimulation and sedation responses to alcohol [ Time Frame: 1 month ]

Original Secondary Outcome: Same as current

Information By: Yale University

Dates:
Date Received: January 23, 2012
Date Started: January 2012
Date Completion:
Last Updated: May 16, 2017
Last Verified: May 2017