Clinical Trial: Family History Study of Alcohol Consumption Using Memantine
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: NMDA Antagonist Efficacy in Reducing Human Alcohol Consumption: Impact of Family History
Brief Summary: The purpose of this study is to evaluate the effects of the study medication, memantine (placebo, 20 mg or 40 mg/day) on alcohol drinking behavior in a laboratory setting in which participants are given an initial drink of alcohol followed by the choice to drink up to 12 more drinks over a three-hour period. We hypothesize that memantine will reduce craving and number of drinks consumed prior to and after exposure to the initial drink of alcohol and during the three hour drinking period. We will also evaluate the influence of family history of alcoholism on the efficacy of memantine in reducing alcohol drinking behavior.
Detailed Summary:
Sponsor: Yale University
Current Primary Outcome:
- Number of Drinks Consumed on Day 7 [ Time Frame: Day 7 ]
- Baseline-adjusted Craving (YCS) [ Time Frame: Day 7 ]Craving for alcohol based on Yale Craving Scale, scores ranging from 0-112 mm on a visual analog scale, with higher measurements indicating higher craving. The baseline-adjusted craving is change score from baseline at Day 7.
Original Primary Outcome: number of drinks consumed [ Time Frame: 7 days ]
Current Secondary Outcome: Stimulation and Sedation Responses to Alcohol [ Time Frame: Day 7 ]
Original Secondary Outcome: Stimulation and Sedation Responses to Alcohol [ Time Frame: 7 days ]
Information By: Yale University
Dates:
Date Received: February 27, 2008
Date Started: June 2006
Date Completion:
Last Updated: November 3, 2016
Last Verified: November 2016
