Clinical Trial: Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: Prospective, Multi-Center Survey Study of Children and Adolescents With Craniopharyngioma
Brief Summary:
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment. It may also help identify the intermediate- and long-term effects of treatment.
PURPOSE: This clinical trial is collecting information on diagnosis, treatment, and quality of life of young patients who are undergoing surgery for craniopharyngioma.
Detailed Summary:
OBJECTIVES:
Primary
- Identify all applied therapy strategies in pediatric patients with craniopharyngioma.
- Correlate relapse status with different therapy strategies/modality in these patients.
- Determine the health status (i.e., ophthalmologic, neuropediatric, and endocrine findings) and the health-related quality of life of these patients after treatment.
Secondary
- Determine the incidence of craniopharyngioma in pediatric patients.
- Identify quality control measures for diagnosis and therapy in these patients.
- Improve long-term care through a standardized follow-up program in these patients.
- Determine the efficacy of endocrine substitution for postoperative hypopituitarism in these patients.
- Identify risk factors for developing obesity and correlate the neurotransmitter concentration of leptin and neuropeptide Y in cerebral spinal fluid, serum, and craniopharyngioma cystic fluid with the likelihood of developing obesity in these patients.
- Determine the incidence and extent of eating disorders in these patients.
OUTLINE: This is a multicenter study.
Patients undergo neurologic, endocrine, and ophthalmologic tests and anthropometric diagnostic measurements. Patients then undergo 1 of the following surgical procedures: total resection; incomplete, subtotal, or partial resection; biopsy; or cyst pressure release. P
Sponsor: Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Cancer Institute (NCI)
Dates:
Date Received: November 22, 2005
Date Started: May 2001
Date Completion:
Last Updated: August 1, 2013
Last Verified: October 2007