Clinical Trial: Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma

Brief Summary: With the preliminary anatomical and histological study, the membranous structures of the sellar region was considered to be closely related with the growth pattern of Craniopharyngiomas(CP). By combined considering of the tumor-membrane relationship, this project was trying to classify the CP through retrospectively summarizing the pre- and postoperative imaging (MRI and CT), the intrasurgical findings, and the endocrine data of 198 CPs with primary surgery in our hospital (since 1997 until now). As a result, a distinct and systematic CP classification was proposed. The possible originate site, surgical skills and postoperative treatment of all the subtype tumors were discussed and analyzed to provide a normalized surgical treatment for this kind of tumor. Then in the prospective cohort, the anticipated 100 CP patients will accept the normalized surgical treatment. And by the long term follow up, the postsurgical quantity of life (QOL) of patients was evaluated with aspect in cognition, circadian rhythm, endocrine, Water-Electrolyte and body weight, et al. By comparing with the long-term results of the retrospective cohort, the totally follow up data was statistically analyzed to assess the rationality of this standard treatment of CP.

Detailed Summary:
Sponsor: Southern Medical University, China

Current Primary Outcome:

  • The course of suprasellar arachnoid mater and pia mater, and the construction of all meninges of the sellar region was observed and measured by microscopy. [ Time Frame: 1~2 years ]
  • Through the analysis of the pre- and postoperative imaging and intrasurgical findings of CP, and combined considering of the tumor-membrane relationship, the classification of CP was proposed. [ Time Frame: 1~2 years ]
  • After long term follow up of CP patients, the normalized treatment was evaluated and modified. [ Time Frame: 3~5 years ]


Original Primary Outcome: The course of suprasellar arachnoid mater and pia mater, and the construction of all meninges near of pacchionian foramen was observed under microscopy. [ Time Frame: 2~7 years ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Southern Medical University, China

Dates:
Date Received: July 21, 2009
Date Started: September 1997
Date Completion: December 2015
Last Updated: September 14, 2010
Last Verified: September 2010