Clinical Trial: Acute Coronary Syndrome Genetic Study

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Comprehensive Intervention and Outcome Research Programs for Acute Coronary Syndrome

Brief Summary: To describe the role of genetic factors and its relationship and interaction with environmental factors in the recurrence of cardiac events in Chinese patients with acute coronary syndrome.

Detailed Summary:

  • Research cohort: Patients diagnosed with acute coronary syndrome are enrolled and to be followed up for 2 years.
  • Baseline and follow up variables include patients' demographics, medical history, ACS event characteristics, clinical treatment options (interventional cardiology, drug therapy: antithrombotic therapy, other treatments recommended by guidelines ) and follow up events information.
  • Blood Sample collection 4ml of vein blood will be drawed. Centrifugation of plasma and WBC will be done on-site within 30 minutes for DNA extraction. Samples will be stored at -80℃ freezer for subsequent applications.

  • A nested case-controlled study is designed for the genetic analysis:

    1. Cases: Patients suffered from death, myocardial infarction, stroke and coronary revascularization and bleeding during the 2-year follow up. We expected to get 600 cases in the study cohort;
    2. Controls: among patients without any of the above events during follow, matched controls of 1:1 ratio will be selected according to date of admission (± 1 month), age (± 5 years), sex, baseline ACS diagnosis, whether treated with PCI , the same pattern of antithrombotic therapy and the study center.
  • Genotyping Genotype testing using exome DNA chips (Exome Beadchip). Exome Beadchip is a high-throughput DNA chip designed by Illumina's, containing 240,000 SNP on exons in the genome that may lead to functional changes.

  • Analysis:

    1. To analysis the impact o
      Sponsor: Peking University First Hospital

      Current Primary Outcome: Major adverse cardiovascular events [ Time Frame: 2 year ]

      Death, Myocardial infarction, stroke, coronary revascularization


      Original Primary Outcome: Same as current

      Current Secondary Outcome:

      Original Secondary Outcome:

      Information By: Peking University First Hospital

      Dates:
      Date Received: October 14, 2013
      Date Started: July 2012
      Date Completion: December 2016
      Last Updated: June 20, 2016
      Last Verified: June 2016