Clinical Trial: Association Between Telomere Length and Risk of Acute Coronary Syndrome

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Short Telomere Length in Peripheral Blood Leukocyte Predicts the Risk of Acute Coronary Syndrome

Brief Summary: Compelling epidemiological evidence indicates that alterations length of telomere, are associated with the initiation and development of ischemic heart disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood leukocyte could be used as a risk predictor for acute coronary syndrome.

Detailed Summary:
Sponsor: Fourth Military Medical University

Current Primary Outcome: Relative telomere length [ Time Frame: From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days ]

the ratio of telomere repeat copy number(T) to the hemoglobin(HGB) copy number (S) was determined for each sample using standard curves. The derived T/S ratio was proportional to the relative telomere length(RTL). In the second step, the T/S ratio of each sample was normalized to a calibrator DNA to standardize between different PCR runs. The calibrated T/S ratio was then used as the measurement of RTL in this study.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Fourth Military Medical University

Dates:
Date Received: May 14, 2016
Date Started: January 2016
Date Completion:
Last Updated: May 14, 2016
Last Verified: May 2016