Clinical Trial: Normalizing CO2 in Chronic Hyperventilation by a Novel Breathing Mask: A Pilot Study

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: CO2 Rebreathing by a Partial Rebreathing Mask as a Treatment of Chronic Idiopathic Hyperventilation - a Pilot Study

Brief Summary:

Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively. The investigators hypothesised that by periodically inducing normocapnia over several weeks, it would be possible to raise the normal resting level/set point of CO2 and achieve a reduction of symptoms.

Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing mask. The mask was used to induce normocapnia in these chronically hypocapnic patients.

Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline and once each week at least three hours after mask use, as well as spirometric values, breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire (NQ),.


Detailed Summary:
Sponsor: University of Aarhus

Current Primary Outcome: Blood gas and acid/base status [ Time Frame: Once every week in the treatment period of four weeks ]

pH, PCO2, PO2, Standard Base Excess


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Hyperventilation symptoms [ Time Frame: once a week ]
    Nijmegen Questionnaire
  • Breath Hold Tolerance [ Time Frame: once a week ]
  • Spirometric values [ Time Frame: once a week ]
    FEV1, FVC


Original Secondary Outcome: Same as current

Information By: University of Aarhus

Dates:
Date Received: April 10, 2012
Date Started: February 2011
Date Completion:
Last Updated: May 18, 2016
Last Verified: May 2016