Clinical Trial: Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational
Official Title: Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers
Brief Summary:
Purpose
- To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.
- To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.
Detailed Summary:
Sponsor: University Hospital Inselspital, Berne
Current Primary Outcome: Capability of urinary acidification [ Time Frame: Five to six hours ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Polymorphisms in the ATP6V1 gene [ Time Frame: 12 months ]
Original Secondary Outcome: Same as current
Information By: University Hospital Inselspital, Berne
Dates:
Date Received: September 10, 2012
Date Started: September 2012
Date Completion: September 2017
Last Updated: November 24, 2016
Last Verified: November 2016
