Clinical Trial: Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis

Brief Summary:

Autoimmune diseases represent a heterogeneous group of pathologies whose etiopathogenic mechanisms are most often unknown. Autoimmune diseases are the leading cause of morbidity and mortality in young women and autoimmune thyroid diseases are the most common.

Viral infections are the main environmental factors suspected of triggering autoimmune diseases. Several viruses are certainly involved, all of which are possibly capable of triggering an autoimmune response. However, the precise identification of the viruses involved remains to be established.

It has been shown for the first time by the 2005 PHRC that enteroviral RNA is present in perioperative specimens of thyroid tissue. However, this case-control study did not show any difference between the thyroid group and the group other thyroid pathologies It has been recently published that Parvovirus is possibly involved in thyroiditis: the parvoviral genome is present in the thyroid tissue of Hashimoto thyroiditis operated and more precisely is present within the thyrocytes itself.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire, Amiens

Current Primary Outcome: Analysis of the viral genome by PCR carried out in the Virology department, Analysis of the presence of capsid protein [ Time Frame: 1 day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire, Amiens

Dates:
Date Received: April 11, 2017
Date Started: January 6, 2012
Date Completion:
Last Updated: April 11, 2017
Last Verified: April 2017