Clinical Trial: Identification of Genes Involved in Juvenile Idiopathic Arthritis by Wholel Exome Sequencing

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Identification of Genes Involved in Juvenile Idiopathic Arthritis by Wholel Exome Sequencing

Brief Summary: Juvenile idiopathic arthritis (JIA) is considered to be a multifactorial disease caused by a combination of environmental factors and predisposing genetic factors. Twins studies found a strong heritability (strong genetic factors) but genetic studies such association studies of large cohorts of patient (GWAS or Genome Wide Association Study) have elucidated less than 20 % of the genetic basis of JIA. The vision of the genetics of multifactorial diseases has recently changed revealing a large clinical and genetic heterogeneity of these diseases. Indeed, the advent of next-generation sequencing identified non-multifactorial genetic hereditary disease related to mutations in genes having strong effect on the onset of the disease without real impact of environmental factors among the so called "multifactorial diseases" (Parkinson's, diabetes, osteoarthritis, Alzheimer's, hypertension ...)The investigators propose to study 30 families with several forms of JIA by next-generation sequencing. Identifying the genetic basis of JIA in these families will help to better understand the physiopathology of this disease and may help to the identification of novel therapeutic targets for other patients with JIA.

Detailed Summary:
Sponsor: University Hospital, Montpellier

Current Primary Outcome: Identification of new genes by Next Generation Squencing (NGS) [ Time Frame: 1 day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Montpellier

Dates:
Date Received: February 13, 2014
Date Started: March 2014
Date Completion:
Last Updated: February 17, 2014
Last Verified: February 2014