Clinical Trial: Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Double-blind Randomized Trial Investigating the Use of Computational Modeling to Predict Rehabilitation Outcomes in Bilingual Aphasia

Brief Summary: The purpose of this investigation is to implement a computational model that can predict and optimize training and cross-language generalization patterns for bilingual persons with aphasia (BPA). The proposed work will determine the best possible treatment program for each individual patient even before they are rehabilitated. In addition, the computational model allows specification of variables such as age of acquisition, language exposure/proficiency, impairment and their systematic influence on a range of language rehabilitation outcomes.

Detailed Summary:
Sponsor: Boston University Charles River Campus

Current Primary Outcome: Word Retrieval Accuracy in both languages [ Time Frame: Through study completion, an average of 10 weeks ]

Accuracy of naming of pictured treated and untreated items in both languages will be assessed in probes conducted separate from treatment. Probes were conducted repeatedly throughout the study, from baseline (prior to treatment) to the end of treatment. All naming responses were scored using as correct or incorrect. A percentage accuracy was calculated for each set of items for every probe session. Baseline probe scores were compared to end of treatment probe scores to obtain individual effect sizes for each sets of items for each participant (i.e., several effect sizes were calculated for each participant).


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Psycholinguistic assessments of language processing in aphasia (PALPA) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Reading single words and understanding spoken words
  • Boston Naming Test (BNT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Naming pictured items
  • Bilingual Aphasia Test (BAT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses each of the languages of a bilingual or multilingual individual with aphasia
  • Western Aphasia Battery (WAB) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses the levels of impairment of aphasia
  • Cognitive Linguistic Quick Test (CLQT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses the contribution of cognitive deficits to language dysfunction
  • Peanut Butter and Jelly Discourse task in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Determines narrative discourse abilities
  • Verbal fluency task (COWAT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses general fluency
  • Category fluency task in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses category fluency
  • Communication Effectiveness Index (CETI) for both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Determines communication effectiveness by proxy
  • Pyramids and Palm Trees Test (PPT) 3 pictures version [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses semantic processing ability


Original Secondary Outcome:

  • Psycholinguistic assessments of language processing in aphasia (PALPA) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Reading single words and understanding spoken words
  • Boston Naming Test (BNT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Naming pictured items
  • Bilingual Aphasia Test (BAT) in both languages [ Time Frame: Week 1 and up to 10 weeks ]
    Assesses each of the languages of a bilingual or multilingual individual with aphasia


Information By: Boston University Charles River Campus

Dates:
Date Received: September 16, 2016
Date Started: October 2016
Date Completion: June 2021
Last Updated: April 25, 2017
Last Verified: April 2017