Clinical Trial: Aneuploidies and Different Stimulation Protocols

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Influence of Ovarian Stimulation and Embryo Aneuploidy

Brief Summary: Our working hypothesis is that patients undergoing "in vitro" fertilization (IVF) with higher response to ovarian stimulation protocols recover a higher number of oocytes and, this elevated response could be translated into increased incidence of chromosomally abnormal embryos. Our objective is to develop a prospective study on healthy young donors, with a previous cycle with high ovarian response (>20 oocytes and/or E2 levels the day of the hCG injection >3000 pg/mL), but without developing mild or severe hyperstimulation syndrome. After signing a proper written consent, these donors would agree to undergo two subsequent stimulation cycles following two different protocols. In one cycle the stimulation pattern would be similar to the previous one, with elevated response and, in another cycle the amount of gonadotropins would be cut down in order to obtain lower ovarian response. Oocytes obtained in each cycle would be donated to anonymous recipients and after fertilization, embryo quality and chromosomal status of the resulting embryos would be evaluated. Preimplantation genetic diagnosis (PGD) will be performed on day-3 embryos and chromosomes 13, 15, 16, 17, 18, 21, 22, X and Y would be analyzed by fluorescence "in situ" hybridization (FISH).

Detailed Summary:
Sponsor: Instituto Valenciano de Infertilidad, IVI VALENCIA

Current Primary Outcome: Aneuploidy rate with two different stimulation protocols. [ Time Frame: three months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Normal blastocyst rate [ Time Frame: three months ]

Original Secondary Outcome: Same as current

Information By: Instituto Valenciano de Infertilidad, IVI VALENCIA

Dates:
Date Received: December 3, 2008
Date Started: December 2008
Date Completion:
Last Updated: September 17, 2009
Last Verified: September 2009