Clinical Trial: Study the Role of T Lymphocytes in Autoimmune Hemolytic Anemia
Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional
Official Title: Study of T Follicular Helper Lymphocytes in Autoimmune Hemolytic Anemia
Brief Summary:
T follicular helper lymphocytes are involved in the pathophysiology of autoimmune diseases. In humans, an increase in the proportion of circulating follicular helper T lymphocytes is observed in systemic lupus erythematous, Sjögren syndrome. No study has yet been conducted in patients with autoimmune hemolytic anemia. In another autoimmune cytopenia, immunological thrombocytopenia pathogenesis (ITP), the investigators showed for the first time an increase in circulating TFH and splenic TFH and their implication in the activation of autoreactive B lymphocytes.
Hypothesis is that autoimmune hemolytic anemia is associated with an increase in the number and/of function of TFH, which thus participate in the hyperactivation of B lymphocytes.
The demonstration that TFH are implicated in autoimmune hemolytic anemia will rapidly lead to the use of targeted therapies to inhibit these cells. These treatments are in the clinical phase of development in other autoimmune diseases.
This study is interventional because of a lots of blood sample
Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Dijon
Current Primary Outcome:
- Compare the proportion of circulating T follicular helper lymphocytes (TFH) in patients with Autoimmune Hemolytic Anemia (AIHA), at diagnosis, with the proportion of circulating T follicular helper lymphocytes (TFH) in control subjects. [ Time Frame: day one ]
- number of T follicular helper lymphocytes in the blood when patients are treated with corticoids [ Time Frame: through study completion, an average of 1 year ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Centre Hospitalier Universitaire Dijon
Dates:
Date Received: June 23, 2016
Date Started: June 2016
Date Completion:
Last Updated: July 7, 2016
Last Verified: July 2016