Clinical Trial: Effects of Stimulant Dependence on Human Striatal Dopamine System - 15

Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional

Official Title: Effects of Stimulant Dependence on Human Striatal Dopamine System

Brief Summary: The purpose of this study is to determine whether DAT availability, assessed by WIN binding, in the striatum is altered in cocaine or methamphetamine dependence. To determine whether DA synthesis capacity, assessed by FDOPA uptake, in the striatum is altered in Coc or Meth dependence. To determine whether the PET tracers, WIN or FDOPA, will differentiate Meth induced alterations from those induced by Coc use. To determine whether the PET characterization of striatal alterations observed at 3-5 days since last drug use persists at least 3 months after last drug use.

Detailed Summary: 4-5 Day inpatient study. Participant will have scanned pictures (MRI & PET scans) taken of their brain after being injected with a small amount of WIN, a radioactive substance. Participants give daily urine samples and fill out health related questionnaires. It is important to determine whether the alterations characterized within one week of last drug use persist over a longer time period. Based on results of the studies from aims 1 & 2, we will decide which of the 2 probes, WIN or FDOPA-PET is the more sensitive index of stimulant-dependency-induced changes.
Sponsor: National Institute on Drug Abuse (NIDA)

Current Primary Outcome:

Original Primary Outcome:

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Original Secondary Outcome:

Information By: National Institute on Drug Abuse (NIDA)

Dates:
Date Received: September 20, 1999
Date Started: March 1999
Date Completion:
Last Updated: January 10, 2017
Last Verified: March 1999