Clinical Trial: Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management

Brief Summary: Cognitive-behavioral coping skills therapy (CBT) is a widely used and recognized treatment that has been empirically validated for a range of substance use disorders, often with emergent effects and continuing improvement even after treatment ends. Treatment retention and compliance are associated with enhanced treatment outcomes in CBT. Contingency management (CM) also has very strong support and is associated with rapid, robust effects on targeted outcomes. Despite their many strengths, neither CBT nor CM is universally effective. It is now essential to seek strategies to maximize and extend the effectiveness of these two approaches and to better understand how these treatments exert their effects.

Detailed Summary: The investigators propose to evaluate targeted strategies to maximize the effectiveness of CBT and CM, respectively. To maximize the effectiveness of CBT, the investigators will evaluate the benefit of adding CM, with reinforcement for session attendance and homework completion, to standard individual CBT for outpatient marijuana abusers, in order to expose participants to more skill training and opportunities for practice of skills. To maximize the effectiveness and durability of CM, we will evaluate the benefit of integrating it with skills training, specifically designed to reduce drop off effects, in order to extend CM's benefits beyond the active treatment period. We propose to conduct a Stage II trial which will: (1) Evaluate the efficacy of four conditions for 160 marijuana dependent outpatients: (a) Standard CBT, (b) CBT with CM reinforcement for attendance and completing homework (CBT+CM/adherence), (c) CM for abstinence alone (CM/abstinence), (d) CM for abstinence integrated with CBT (CM/abstinence+CBT), and (2) Evaluate the longer-term durability and / or delayed emergence of treatment effects after termination of the study treatments through a one-year follow-up. Secondary aims will be to conduct (a) detailed process studies to evaluate whether the proposed enhancements affect proximal and distal outcomes as hypothesized and (b) economic analyses. Study treatments will last 12 weeks.
Sponsor: Yale University

Current Primary Outcome: Self reported marijuana use (days of abstinence by week) and results of urine toxicology screens [ Time Frame: 12 weeks ]

Original Primary Outcome:

  • Evaluate the efficacy of four conditions for 160 marijuana dependent outpatients:
  • Standard CBT
  • CBT with CM reinforcement for attendance and completing homework (CBT+CM/adherence)
  • CM for abstinence alone (CM/abstinence)
  • CM for abstinence integrated with CBT (CM/abstinence+CBT)
  • Evaluate the longer-term durability and / or delayed emergence of treatment effects after termination of the study treatments


Current Secondary Outcome: Economic analysis with use of PACC-SAT [ Time Frame: 12 weeks ]

Original Secondary Outcome:

  • detailed process studies to evaluate whether the proposed enhancements affect proximal and distal outcomes as hypothesized and
  • economic analyses.


Information By: Yale University

Dates:
Date Received: July 7, 2006
Date Started: December 2004
Date Completion:
Last Updated: September 26, 2011
Last Verified: September 2011