Clinical Trial: Estimation of Pentrexin-3 Levels in GCF and Saliva of Patients With Periodontal Disease

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Assessment of Pentraxin-3 Levels in Gingival Crevicular Fluid and Saliva in Periodontal Health and Disease

Brief Summary: Subjects were selected from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Oral and Dental Medicine, Cairo University. Ten healthy control subjects presented with clinically healthy periodontium. Ten patients who had plaque induced gingivitis. Ten patients who had generalized chronic periodontitis. Ten patients who had generalised aggressive periodontitis. Pentraxin-3 levels were evaluated in GCF and saliva of all subjects included in this study with ELISA technique.

Detailed Summary:

The study population consisted of 4 groups of forty patients selected as follows:

Group 1 - Healthy Controls:

Ten healthy control subjects presented with clinically healthy periodontium. Control subjects had to meet the following criteria for inclusion: probing depth less than 3mm, no clinical attachment loss, no bleeding on probing, with Gingival and Plaque index 0-1.

Group 2 - Plaque induced gingivitis patients:

Ten patients who had plaque induced gingivitis characterized by the presence of any of the following clinical signs: redness and edema of the gingival tissue, bleeding upon provocation, changes in contour and consistency, presence of calculus and/or plaque, with no clinical attachment loss nor radiographic evidence of bone loss.

Group 3 - Chronic periodontitis group:

Ten chronic moderate to severe periodontitis patients selected according to the criteria currently adopted by Armitage 1999. Moderate destruction is generally characterized by periodontal probing depths up to 6 mm with clinical attachment loss of up to 4 mm. Advanced destruction is generally characterized by periodontal probing depths greater than 6 mm with attachment loss greater than 4 mm. Radiographic evidence of bone loss is apparent, Increased tooth mobility may be present.

Group 4 - Aggressive periodontitis group:

Ten patients suffering generalized aggressive periodontitis, patients were less than 35 years of age and had generalized interproximal attachment loss affecting at least 3 permanent teeth other than the first molars and incisors with at lea
Sponsor: Cairo University

Current Primary Outcome: GCF and salivary pentraxin-3 levels [ Time Frame: baseline ]

levels of pentraxin-3 in GCF and saliva


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • plaque index [ Time Frame: baseline ]
    Oral hygiene status of the patients were recorded using the plaque index of Silness & Lӧe (1964)
  • gingival index [ Time Frame: baseline ]
    Performed using the gingival index of Lӧe (1967)
  • probing pocket depth [ Time Frame: baseline ]
    The depths of the periodontal pockets were measured as the distance from the gingival margin to the base of the pocket using periodontal probe with William's graduation.
  • clinical attachment level [ Time Frame: baseline ]
    Clinical attachment levels were measured as the distance from the CEJ to the base of the pocket using William's graduated periodontal probe.


Original Secondary Outcome: Same as current

Information By: Cairo University

Dates:
Date Received: April 21, 2017
Date Started: December 2015
Date Completion:
Last Updated: April 21, 2017
Last Verified: April 2017