Clinical Trial: Clarithromycin as Adjuvant to Periodontal Debridement

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial

Brief Summary: To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.

Detailed Summary: To assess the periodontal clinical response and the possible adverse effects of the clarithromycin combined to periodontal mechanical therapy in the treatment of patients with generalized aggressive periodontitis.Forty patients were select and randomly assigned into two groups: Group clarithromycin with 20 subjects that received one-stage full-mouth ultrasonic debridement (FMUD) associated with clarithromycin (500 mg - 12/12 hours) for 3 days; group placebo with 20 subjects that received FMUD associated with placebo. Probing depth (PD), gain in clinical attachment level (CAL) and bleeding on probing (BOP) were evaluated at baseline, 3 and 6 months post- operatively.
Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho

Current Primary Outcome: Clinical attachment level [ Time Frame: 6 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Probing depth [ Time Frame: 6 months ]

Original Secondary Outcome: Same as current

Information By: Universidade Estadual Paulista Júlio de Mesquita Filho

Dates:
Date Received: July 8, 2016
Date Started: March 2014
Date Completion:
Last Updated: July 12, 2016
Last Verified: July 2016