Clinical Trial: Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Subgingival Microbiome Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Aggressive Periodontitis Patients

Brief Summary: The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement. The investigators designed to observe the changes after mechanical treatment.Then, the investigators will compare the sub-mucosa microbiome of implant and the subgingival community. The investigators expected a different community after treatment, and there could be similarity between implant and nature teeth.

Detailed Summary:
Sponsor: Peking University

Current Primary Outcome:

• changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community) [ Time Frame: Baseline, 6 weeks after mechanical treatment ]
  the diversity of subgingival community before and after mechanical treatment
• changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community) [ Time Frame: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years. ]
  the diversity of submucosa community before and after implatation
• changes of prevalence and abundance of OTUs [ Time Frame: Baseline, 6 weeks after mechanical treatment ]
  compute and compare the prevalence and abundance of OTUs
• changes of prevalence and abundance of OTUs [ Time Frame: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years. ]
  compute and compare the prevalence and abundance of OTUs

Original Primary Outcome: Same as current

Current Secondary Outcome:

• changes of bleeding index [ Time Frame: Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. ]
  bleeding index after probing
• changes of probing depth [ Time Frame: Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. ]
  probing depth of indicated sites
• clinical attachment loss [ Time Frame: Baseline, 6 weeks after mechanical treatment, before implantation, 1 months after second stage surgery, every month after prosthetic treatment until 2 years. ]
  by probe, the distance between CEJ and gingival sulcus

Original Secondary Outcome: Same as current

Information By: Peking University

Dates:
Date Received: March 9, 2017
Date Started: March 2, 2016
Date Completion: January 1, 2018
Last Updated: March 23, 2017
Last Verified: March 2017