Clinical Trial: Efficacy of Three Antibiotic Protocols for Aggressive Periodontitis Treatment

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Efficacy of Moxifloxacin, Amoxicillin+Metronidazole for Aggressive Periodontitis Treatment

Brief Summary: The aim of the present study is to evaluate the clinical and microbiological efficacy of moxifloxacin or amoxicillin plus metronidazole in one-stage scaling and root planing in treating generalized aggressive periodontitis. Forty five subjects will be randomly allocated to 3 treatment groups. Subgingival plaque samples will be analysed for cultivable bacteria. The primary outcome variable to determine the superiority of one treatment over the others would be differences between groups for means CAL changes at 6 months post-treatment. Secondary outcome variables include differences between therapies for the mean changes in the mean levels of PD and the proportion of BOP.

Detailed Summary:
Sponsor: Facultad Nacional de Salud Publica

Current Primary Outcome: clinical attachment level [ Time Frame: 3 and 6 months ]

It was defined that the primary outcome variable to determine the superiority of one treatment over the other would be differences between groups for means Clinical Attachment Level changes at 6 months post-treatment. This is a measure assessing change between two time points .


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Facultad Nacional de Salud Publica

Dates:
Date Received: May 31, 2016
Date Started: December 2015
Date Completion: June 2017
Last Updated: July 18, 2016
Last Verified: July 2016