Clinical Trial: Serial Changes of Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) Levels in Patients With Acute Respiratory Distress Syndrome
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Serial Changes of sTREM-1 Levels in Patients With Acute Respiratory Distress Syndrome
Brief Summary: The purpose of this study is to determine the impact of the serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) on etiology and prognosis of acute respiratory distress syndrome (ARDS)
Detailed Summary: The triggering receptor expressed on myeloid cells-1 (TREM-1), a member of the immunoglobulin superfamily, is upregulated on phagocytic cells in the presence of bacteria or fungi infection and weakly expressed in samples from patients with noninfectious inflammatory disorders. In addition, TREM-1 is shed from the membrane of activated phagocytes and can be found in a soluble form (sTREM-1) in body fluids. The level and serial change of a serum sTREM-1 from cirtical ill patients has been shown to be a good diagnostic and prognostic indicator of ventilation associated pneumonia (VAP) and severe sepsis.
Sponsor: National Taiwan University Hospital
Current Primary Outcome:
- all cause mortality [ Time Frame: 28 days ]
- Septic or non-septic etiology [ Time Frame: At enrollment ]
Original Primary Outcome:
- all cause mortality [ Time Frame: 28 days ]
- Infectious or non-infectious etiology [ Time Frame: At enrollment ]
Current Secondary Outcome:
- CRP, lactate, WBC count, APACHE II score, LIS, SOFA score [ Time Frame: At enrollment ]
- IL-1 beta, IL-8, TNF-alpha [ Time Frame: serial follow up at Day 1, 3, 5, 7, 14 ]
Original Secondary Outcome: CRP, lactate, WBC count, APACHE II score, LIS, SOFA score [ Time Frame: At enrollment ]
Information By: National Taiwan University Hospital
Dates:
Date Received: November 12, 2007
Date Started: October 2007
Date Completion:
Last Updated: May 8, 2008
Last Verified: May 2008
