Clinical Trial: Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Measurement of Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury Using Electrical Impedance Tomography
Brief Summary: The purpose of this study is the measurement of regional opening and closing pressures of lung tissue by electrical impedance tomography in lung healthy and patients with acute lung injury. These values might help the setting of positive endexpiratory pressure during artificial ventilation to avoid the cyclic opening and closing of alveoli.
Detailed Summary:
During artificial ventilation the cyclic opening and closing of alveoli during artificial ventilation results in patients with acute lung injury (ALI) in a higher mortality. A positive endexpiratory pressure (PEEP) is applied with the intention to avoid these cyclic opening and closing of alveoli. The distribution of ventilation in patients with ALI is extremely inhomogeneous, consequently there are different regional opening pressures needed to open up the alveoli and avoid closing. Finding the best level of PEEP in patients with injured lungs to avoid atelectasis and alveolar strain induced by inadequately high or low PEEP levels is a challenge.
The purpose of this study is to develop a protocol for measuring regional opening and closing pressures using the method of electrical impedance tomography in lung healthy and ALI patients. A ventilator setting guided by regional opening and closing pressures might help reducing the impairment of the lung by artificial ventilation.
Sponsor: University of Schleswig-Holstein
Current Primary Outcome: Measurement of regional lung opening pressures [ Time Frame: one year ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Measurement of regional closing pressures [ Time Frame: one year ]
Original Secondary Outcome: Same as current
Information By: University of Schleswig-Holstein
Dates:
Date Received: April 19, 2010
Date Started:
Date Completion:
Last Updated: April 20, 2010
Last Verified: March 2010