Clinical Trial: Remote Ischemic Preconditioning and Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Stent Implantation
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title: Remote Ischemic Preconditioning and Risk of Contrast-Induced Acute Kidney Injury in Patients Undergoing Coronary Stent Implantation
Brief Summary: This single-center, randomized controlled trial is to investigate the impact of remote ischemic preconditioning (RIPC) on the risk contrast-induced acute kidney injury and its long-term impact on renal function for patients with diabetes undergoing percutaneous coronary intervention.
Detailed Summary: Patients with diabetes undergoing elective percutaneous coronary intervention in Beijing Anzhen Hospital were enrolled, and all the eligible participants were randomized to either remote ischemic preconditioning (RIPC) group or control group. Those randomized to RIPC group had a pneumatic medical tourniquet cuff (width , 5 cm ; length , 40 cm) placed around their upper arm at < 2 hours before the PCI procedure. The pneumatic medical cuff was inflated to a pressure of 200 mm Hg for 5 minutes , followed by 5 minutes of deflation to allow reperfusion. This procedure was repeated for 3 times. Control participants did not experience this procedure of transient upper-limb ischemia.
Sponsor: Beijing Anzhen Hospital
Current Primary Outcome: acute kidney injury [ Time Frame: 72 hours after procedure ]
Original Primary Outcome: Same as current
Current Secondary Outcome: relative reduction in estimated glomerular filtration rate [ Time Frame: 180 days after procedure ]
Original Secondary Outcome: Same as current
Information By: Beijing Anzhen Hospital
Dates:
Date Received: March 31, 2013
Date Started: March 2012
Date Completion: June 2013
Last Updated: April 9, 2013
Last Verified: April 2013