Clinical Trial: Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?

Brief Summary: In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Detailed Summary:
Sponsor: Hacettepe University

Current Primary Outcome:

• RANKL (pmol) level in GCF [ Time Frame: Baseline-3 months ]
  Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
• OPG level (pg) in GCF [ Time Frame: Baseline-3 months ]
  Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
• RANKL/OPG ratio [ Time Frame: Baseline - 3months ]
  RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis

Original Primary Outcome: Same as current

Current Secondary Outcome:

• IL-1β (pg) levels in GCF [ Time Frame: Baseline, 3 months after treatment ]
  Changes in IL-1β levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive Periodontitis groups
• Il-10 (pg) levels in GCF [ Time Frame: Baseline-3 months ]
  Changes in IL-10 levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis

Original Secondary Outcome: Same as current

Information By: Hacettepe University

Dates:
Date Received: July 8, 2014
Date Started: January 2010
Date Completion:
Last Updated: July 13, 2014
Last Verified: July 2014