Clinical Trial: Chronic Presence of Epstein Barr Virus in Epithelial Cells From Gingiva is Associated With Periodontitis
Study Status: Completed
Recruit Status: Unknown status
Study Type: Interventional
Official Title:
Brief Summary: The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.
Detailed Summary:
Sponsor: Centre Hospitalier Universitaire de Nice
Current Primary Outcome: Percentage of gingival epithelial cells infected by EBV (by immunofluorescence and In situ Hybridization) [ Time Frame: at time=0 ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Epithelial tissue infected by EBV (by immunofluorescence and in situ hybridization) [ Time Frame: at time = 0 ]
- Presence / absence of latency and / or lytic proteins (by immunofluorescence and in situ hybridization) [ Time Frame: at time = 0 ]
Original Secondary Outcome: Same as current
Information By: Centre Hospitalier Universitaire de Nice
Dates:
Date Received: November 17, 2010
Date Started: January 2011
Date Completion: January 2014
Last Updated: December 17, 2012
Last Verified: November 2010
