Clinical Trial: Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Interventional

Official Title: Effects of Local Wound Infiltration With Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress Response and Postoperative Pain in Major Abdominal Cancer Surgery

Brief Summary: This study aims to compare the effects of local wound infiltration with ketamine versus dexmedetomidine when added to bupivacaine on stress response and postoperative pain in lower abdominal cancer surgery.

Detailed Summary:

Patients will be randomly assigned using an online research randomizer into three groups, 30 patients in each group:

Group C:

30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision( control group).

Group K:

30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline +1 mg /kg ketamine (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision.

Group D:

30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline + 1µg/kg dexmedetomidine (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision.


Sponsor: Assiut University

Current Primary Outcome: Total morphine consumption [ Time Frame: 24 hours ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Plasma concentrations of prolactin, cortisol and glucose level [ Time Frame: 24 hours ]
  • the severity of pain was assessed using VAS score [ Time Frame: 24 hours ]


Original Secondary Outcome: Same as current

Information By: Assiut University

Dates:
Date Received: October 5, 2016
Date Started: June 2016
Date Completion: February 2017
Last Updated: January 23, 2017
Last Verified: January 2017