Clinical Trial: Restricted Intravenous Fluid Regime Effects on Immunological Indicators of Elderly Patients Operated for Abdominal Cancer
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title:
Brief Summary: The purpose of this study is to find out whether perioperative fluid restriction influence on postoperative immunological function. And discuss the probable mechanism that fluid restriction regime effect on clinical data.
Detailed Summary:
Perioperative fluid administration is a common therapy in clinical practice, and recent regime has a history about 50 years. Recently, clinicians found that traditional regime had some disadvantages, for example, pulmonary edema, increased cardiac load, increased body weight. And thus, perioperative fluid restriction regimen has been suggested and proved could reduce cardiopulmonary complications and mortality rates after major elective gastrointestinal surgery.
Patients were divided into two groups randomly and underwent restricted fluid regimen or traditional fluid regimen. We determined the complications and immunological function in two groups, and analyzed the relationship between complications and immunological changes. Based on this we decide the probable mechanism that perioperative fluid restriction effects on complications.
Sponsor: Nanjing PLA General Hospital
Current Primary Outcome: clinical perioperative complications [ Time Frame: 30 days after surgery ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- death [ Time Frame: 30 days after surgery ]
- adverse effects [ Time Frame: 30 days after surgery ]ischemia and impairment of renal function
Original Secondary Outcome: Same as current
Information By: Nanjing PLA General Hospital
Dates:
Date Received: July 18, 2011
Date Started: May 2009
Date Completion:
Last Updated: July 21, 2011
Last Verified: May 2009
