Clinical Trial: Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia in Cancer Surgery

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional

Official Title: Effect of Continuous Pre-peritoneal Wound Infiltration Versus Epidural Analgesia on Inflammatory Response in Lower Abdominal Cancer Surgery

Brief Summary: the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response after abdominal cancer surgery

Detailed Summary:
Sponsor: Assiut University

Current Primary Outcome: changes in the level of inflammatory cytokines in pg /ml [ Time Frame: 24 hours ]

Blood samples taken all over the 24-hr. period were collected in plasma tubes containing ethyl-enediamine-tetra-acectic (EDTA), centrifuged and stored at 20○c for assessment of Plasma concentrations plasma IL 1, IL 6, IL10 and TNF to assess inflammatory cytokines


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Visual Analog Scale at rest and on coughing [ Time Frame: 24 hours ]
    pain intensity was assessed using a 10-cm VAS (0 = no pain and 10 = worst imaginable pain)
  • opioid side-effects [ Time Frame: 24 hours ]
    observation of side effects and record incidence as nausea, vomiting and itching
  • patient satisfaction [ Time Frame: 24 hours ]
    scale ranging 1-4 :unsatisfactory, regular, satisfactory and excellent)


Original Secondary Outcome: Same as current

Information By: Assiut University

Dates:
Date Received: December 19, 2016
Date Started: January 2017
Date Completion: March 2017
Last Updated: January 23, 2017
Last Verified: January 2017